Howard Hughes Medical Institute

The Exploratory Instrument

Stuck situations — Interactive visual system

An interactive system built to make the extreme complexity of fruit fly neuron connectivity navigable for researchers.

Fly brain neuron connectivity — full system view

The friction

The Howard Hughes Medical Institute had mapped the neural connectivity of a fruit fly brain — a dataset of extreme density that their own team struggled to navigate. Standard visualization approaches produced unreadable tangles. The complexity was real and the stakes were high: researchers needed to be able to explore and communicate their findings, not just store them.

The parameter shift

Rather than trying to simplify the data, I built a system capable of holding its full complexity. Working in the domain of the maker — before any chart type or layout was decided — I deconstructed the parameters: what does neural connectivity actually mean spatially? What needs to be comparable? What needs to be explorable versus fixed?

The result was a system so architecturally robust that it effectively replicated the institute's own internal analytical tools. It had to be consciously scaled back to function as a companion to the published research rather than replace their entire workflow.

Parameter discovery sketch or early prototype

The system

A bespoke interactive application allowing researchers to navigate between brain regions, trace individual neuron pathways, and compare connectivity patterns across the dataset. One-of-a-kind by design — no template existed for this problem.

Interactive fly brain system — detail view Interactive fly brain system — region navigation

The impact

Researchers could, for the first time, visually explore and communicate the full topology of the fruit fly connectome in a way that was both analytically rigorous and publicly accessible. The system was published alongside the research.

← All work Next: The Experiential Magnet →